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This approach, however, mandates the existence of a well-accepted reference standard.For biomarkers that are used to help treat patients with systemic infections and sepsis there is no such reference standard, with blood cultures having low sensitivity of only 10% to 30%.

He is also correct that the use of anti-eosinophilic biologic agents must be restricted to those patients with evidence of persistent eosinophilic asthma who are not responding to high doses of conventional antiasthma treatment, many of whom require oral corticosteroids to manage their disease. [c:0|t:6|false] OBJECT IDENTIFIER 1.2.840.10045.4.3.2 (ecdsa With SHA256) . [c:0|t:6|false] OBJECT IDENTIFIER 2.5.4.6 (country Name) . However, identifying these patient phenotypes that may potentially respond to a very specific biological treatment, even if they represent a small proportion of the entire patient population with the disease, is the whole purpose of precision medicine.Asthma may also be difficult to control because of poor inhaler technique, comorbidities, and exposure to exacerbating factors.

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